2 MONTHS AGO • 8 MIN READ

🌿 Want To Live to 100? Start Here

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Dr Karan's Weekly Dose

A weekly newsletter to help you live a happier, healthier life!

Ever get tired of all the noise out there about health and wellness when the truth is, it’s usually the simple actionables that fit into your life without breaking the bank that are best?

Well, it’s exactly the same with the microbiome.

In more than 10 years of research, the amount of “tips” I’ve come across that were total nonsense is bonkers. That’s why I’m putting together a simple, actionable microbiome course for everyday people like you and me. Sign up here if you'd like to know more.

What you'll learn in this newsletter:

1. ⚠️ Could Too Much Fiber Be Hurting You?

2. 🌿 Want To Live To 100? Start Here

3. 🫤 Why Smart People Make Bad Decisions

GUT health

⚠️ Could Too Much Fibre Be Hurting You?

Sometimes the problem isn’t how much fiber you’re eating, it’s when you’re eating it.

Too much fibre in one meal can cause more problems than it solves:- bloating, gas, increased hunger.

Take the great British Roast Dinner as an example.

Eaten up and down the British Isles every Sunday lunchtime, a full Roast Dinner comprises roast meat (beef, chicken, turkey, pork), roast potatoes, Yorkshire puddings (if you don’t know what they are, just Google them) and any combination of peas, carrots, broccoli, parsnips, brussel sprouts.

In terms of fiber, you can easily pack in 20g, which is great for a single meal.

Unless, that happens to be the first significant fiber of the day because breakfast was coffee and a muffin.

In that case, the sudden barrage of fiber might simply be too much for one gut to take.

On the other hand, distributing your fiber intake throughout the day will reduce the chances of gut issues, stabilise your hunger pangs and stop you feeling like a human airbag.

Here’s how to add fiber to each meal of the day

1️⃣ Breakfast

Choose wholegrain bread for your toast, add berries or nuts to your porridge or cereal, or eat beans (yes, I eat beans for breakfast every day)

2️⃣ Lunch/Dinner

Whether it’s lunch or dinner, the same rules apply: swap refined grains (white rice, pasta etc) for their wholegrain versions, eat more legumes (chickpeas, lentils), add a serving of vegetables to every meal. And eat more beans.

3️⃣ Snacks

Apples with skin on, berries, nuts, dark chocolate, hummus with carrot sticks. Or beans. Seriously, if you haven’t tried edamame beans as a snack (6g fiber & 12g protein per 100g), you’re missing out.

4️⃣ Water

Don’t forget to drink enough water. More fiber, less fluids = constipation

5️⃣ Diversity

Diversity is the key. Your gut microbes need a varied fiber diet and if you’re eating wholegrain rice for lunch every day, they’re simply not going to get the nourishment they need.

You (and I) could do a lot worse than go back through that list you’ve just read and tick off every food that’s mentioned that you’ve eaten in the last week.

What’s left?

Now you know what’s on the menu for tomorrow.


GENERAL HEALTH

🌿 Want To Live To 100? Start Here

A staggering 10% of the Swedish population - roughly 800,000 people - have donated blood samples to the AMORIS cohort.

These samples were taken between the mid 1980s and mid 1990s, meaning researchers have now had 30-40 years to track the lives of these individuals and correlate life outcomes with biomarkers.

Naturally, some of those people have passed away, many are still alive and some…are more than 100 years old.

More than 1,000 of them in fact.

Would you like to know what a centenarian’s blood sample looked like when they were 65?

Thanks to a 2024 paper (PMID 37726432), we can do just that.

Here are some of the commonalities among the centenarians

  • Lower than average blood glucose levels
  • Lower than average kidney markers, such as uric acid and creatinine
  • Lower than average liver markers, such as gamma-glutamyl transferase (GGT) suggesting reduced liver stress
  • Higher than average iron and total cholesterol
  • Fewer extreme values overall across a wide range of markers

Wait…what? Higher cholesterol?

Yes. But bear in mind that’s total cholesterol - HDL-C, LDL-C, apoB.

Remember: LDL-C and apoB are numbers you may need to reduce (if a doctor tells you they're too high: TDLR get tested asap if you don't know).

If you need a refresher on what these all mean and which of them you should really focus on, you can find out everything here.

So, none of this means any one of these biomarkers leads to increased longevity. If I had to sum it all up in one sentence, it would be this:

People who lived to be centenarians showed remarkable consistency across a range of metabolic health markers.

As in so many areas of life, it’s consistency that wins the race.

With that in mind, here’s how to be consistent in anything - diet, exercise, sleep - to maximise your chances of living long and living well.

How To Make Consistency Inevitable

1️⃣ Lower the bar: commit to the smallest possible version of what you want to do e.g. “I will do 3 press ups as soon as I get up”. If you do more, great; if not, it’s still a win.

2️⃣ Track the process, not the outcome. You can control what you do, not how things turn out.

3️⃣ Leverage accountability: tell someone your objective. They’ll start to expect the behaviour from you and you’ll expect it from yourself.

4️⃣ Reduce the number of decisions you have to make: nothing kills motivation like cognitive load.

Whatever you want to do, you want to make sure it happens on your worst day.

And when it comes to upping your fiber game (a key strategy for controlling blood glucose), the only decision you need to make is to try LOAM. Its 6-in1 fiber formulation has been shown to have positive effects in hours and you won’t notice a thing when you take it: no flavour, no colour, no texture. You can get 10% off your purchase right now by clicking here.

In fact, like these two LOAM users, you might find taking LOAM every day is the only thing you need to do to lower your cholesterol.


REFLECTIONS

🫤 Why Smart People Make Bad Decisions

King Solomon - an ancient King of Israel, important for Jews, Christians and Muslims - was an extraordinary figure.

His most famous act was deciding which of two mothers a baby belonged to when both claimed the child and there was no evidence as to who was telling the truth.

By threatening to slice the child in two and hand a bloody half to each woman, the real mother begged him to hand the baby to the other women.

Knowing only the real mother would be prepared to give her child up rather than see him killed told Solomon everything he knew.

However, despite dishing out sage advice to other people, King Solomon was unable to follow his own advice. In later life, he squandered the state treasury and made decision that ultimately led to his nation being split in two after his death.

Funnily enough, a US Judge by the name of…Solomon Wachtler showed a similar inability to heed his own advice. Despite working in spousal abuse cases for years, in 1993 he pleaded guilty to harassing a former lover and threatening to kidnap her daughter.

Solomon’s Paradox is the observation that we often fail to follow the very good advice we’re able to offer other people.

One reason we might do this is to do with “psychological distance”.

When faced with a personal problem we use a first-person perspective that prevents us from seeing the big picture. But when the problem is someone else's, the extra “psychological distance” favours higher-level thinking that takes a wider context into account.

Therapists encourage clients to use third-person pronouns to refer to themselves to increase psychological distance.

So, these days, when I’m tearing my hair out at 2am with a child who won’t sleep, or receive a call telling me no-one’s picking up the latest shipment of LOAM from the warehouse, I pause.

And ask myself, “what should Karan do right now?”

As woo as it sounds, it works.


👋 Who are you again? I’m Karan Rajan - a doctor and curious explorer of all things health and wellness. I'm the founder of LOAM Science, a microbiome company aiming to create the best fiber product in the world! I host the Dr Karan Explores Podcast, where I talk to experts in science and medicine to cut through the BS of modern health advice. If you'd like an easy way to dig through the archive, you can ask me any questions about the podcast and talk to my digital librarian here. I've also written two books "This Book May Save Your Life" and "This Is Vital Information". I'm the Chief of Science of Throne, a smart gut health tracking device.

If you feel strongly about some health things or just want to say hi? Hit reply... I’d love to hear it and hear from you! (yes I read every reply!!!)

🤩 WEEKLY HIGHLIGHTS

◀️ Should You Really Be Taking Peptides?

Peptides have been having a moment online for what seems like a while now but...how many of us know what a peptide actually is? In this Ask Me Anything episode of the podcast, I explain which of the peptide claims you’ve heard of are warranted and which are just marketing hype. Plus: What is the Wolverine Stack? Watch here

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I Fibermaxxed To Finally Have Perfect Poops

In case you missed it: this recent video explains what most people get wrong about fibermaxxing and why going from zero to hero overnight is an absolute mistake. I also cover how to get up to God-tier levels of fiber per day without turning your kitchen into a rabbit sanctuary. You can watch it here now.

video preview


👶 My Digital Alter Ego

If I say so myself, my recent conversation with Kaitin Colucci about all the things besides food that contribute to gut health was a corker. There are so many simple, but powerful actionables that I could barely keep up when we recorded the conversation. This is where my AI-powered twin is so handy. Just ask him to give you 3 actionable tips from this or any episode and you’ll know what you get back is evidence-based.


📝 WHAT I'M DOING THIS WEEK

🔬Planning New Research For LOAM

We’ve been approached by universities and other institutions who are interested in researching LOAM in different diseases and populations. I am so excited for what new discoveries we can make. I’ve got the lofty (crazy?) aim of making LOAM the most clinically studied fiber supplement in the world…and we’re off to a decent start! 2 clinical studies in just 7 months and hopefully more to come! Allons-y!


🎵 Singing to My Son

Gobbledegook parent talk might sound cute, but it doesn’t do much to engage babies' brains. I’m no Tiger Dad, but I don’t see why I shouldn’t talk to him as much as possible using…well, proper speech. And singing. Actually, I definitely think he falls asleep quicker when I sing to him…something to do with the vibrations when he’s on my chest? Just don’t ask to hear my ‘Bohemian Rhapsody’.

🤖 I Bought a Roomba!

Finally! I’ve often talked of the migrating motor complex in your gut as being like a biological roomba, but I’ve recently landed my very own little cleaning robot. Expensive, but worth it to keep my home nice and dust free. 20-50% of household dust is dead skin cells and keeping homes as dust-free as reasonably possible can help with reducing allergy symptoms.

Disclaimer: This blog is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this blog or materials linked from this blog is at the user’s own risk. The content of this blog is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay seeking medical advice for any medical condition they may have and should consult their healthcare professionals for any such conditions.

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© 2026 Dr Karan's Weekly Dose

Dr Karan's Weekly Dose

A weekly newsletter to help you live a happier, healthier life!